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Gastric microbiota and Helicobacter pylori in Indonesian population

Miftahussurur, Muhammad and Waskito , Langgeng Agung and El-Serag, Hashem B and Ajami, Nadim J. and Nusi, Iswan Abbas and Syam, Ari Fahrial and Matsumoto, Takashi and Rezkitha, Yudith Annisa Ayu and Doohan, Dalla and Fauzia, Kartika Afrida and Maimunah, Ummi and Sugihartono, Titong and Uchida , Tomohisa and Yamaoka, Yoshio (2020) Gastric microbiota and Helicobacter pylori in Indonesian population. Helicobacter, 25 (4). pp. 1-10. ISSN 1083-4389, 1523-5378

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        Abstract

        Background: The profile of gastric mucosal microbiota has not yet been described in the Indonesian population where the prevalence of Helicobacter pylori is low. Methods: This is a cross-sectional study analyzing 16S rRNA of 137 gastric biopsy specimens. We analyzed the association between gastric microbiota, H. pylori infec- tion, and gastric mucosal damage. Result: Among 137 analyzed samples, 27 were H. pylori-positive and 110 were H. pylori -negative based on culture, histology, and 16S rRNA gene analysis. Significantly lower α-diversity parameters, including Pielou's index, was observed in H. pylori-in- fected individuals compared with noninfected individuals (all P < .001). Among H. pylori-negative individuals, the permutational analysis of variance of Bray-Curtis dis- similarity distances showed a significant association with different ethnicities, sug- gesting some ethnic groups had specific microbiota profiles based on the presence of different operational taxonomic units. The linear discriminant analysis effect size (LEfSe) of the H. pylori-negative group showed significant associations between the presence of Micrococcus luteus and Sphingomonas yabuuchiae with Timor and Papuan ethnicities, respectively. The presence of Bulledia sp and Atopobium sp was associated with the Javanese ethnicity. We observed lower α-diversity scores in individuals with gastric mucosal damage and profiles with high abundances of Paludibacter sp and Dialister sp based on LEfSe analysis.

        Item Type: Article
        Uncontrolled Keywords: Helicobacter pylori, Indonesia, microbiome
        Subjects: Q Science > QR Microbiology
        R Medicine > R Medicine (General)
        Divisions: Jurnal > Fakultas Kedokteran
        Depositing User: YUDITH ANNISA AYU REZKITHA
        Date Deposited: 14 Aug 2020 13:38
        Last Modified: 18 Nov 2020 10:53
        URI: http://repository.um-surabaya.ac.id/id/eprint/4231

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