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Coronavirus Disease 2019 (COVID-19): Patogenesis, Manifestasi Klinis dan Pilihan Terapi

Levani , Yelvi and Dwi Prastya, Aldo and Mawaddatunnadila, Siska (2021) Coronavirus Disease 2019 (COVID-19): Patogenesis, Manifestasi Klinis dan Pilihan Terapi. Jurnal Kedokteran dan Kesehatan, 17 (01). pp. 44-57. ISSN 2549-6883

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        Abstract

        ABSTRAK Coronavirus Disease 2019 (COVID-19) ditemukan pada akhir tahun 2019 tepatnya bulan Desember di Kota Wuhan, Provinsi Huebei, China dan kemudian menyebar ke hampir seluruh dunia. Covid-19 disebabkan oleh betacoronavirus jenis baru yang cenderung mirip SARS-CoV dan MERS-CoV. Tujuan penulisan ini untuk memberikan telaah mengenai patofisiologi, manifestasi klinis, dan perkembangan penelitian tatalaksana Covid-19. Jenis review yang digunakan dalam artikel ini berbentuk literature review terhadap 41 artikel Covid-19 dengan menggunakan database PubMed dan Google Scholar. Covid-19 termasuk dalam genus betacoronavirus, hasil anasilis menunjukkan adanya kemiripan dengan SARS. Gejala umum di awal penyakit adalah demam, kelelahan atau myalgia, batuk kering. Serta beberapa organ yang terlibat seperti pernapasan, gastrointestinal, dan neurologis. Sampai saat ini, WHO dan beberapa Negara sedang melaksanakan uji klinis untuk menemukan obat yang tepat untuk Covid19, studi ini bernama SOLIDARITY. Terdapat 4 kelompok dalam studi ini, yaitu kelompok LPV/r dan Interferon-beta, Remdesivir, Klorokuin dan Hidroksiklorokuin. Faktor virus dengan respon imun menentukan keparahan dari infeksi Covid-19. Gejala umum di awal penyakit adalah demam (83-98%), kelelahan atau myalgia, batuk kering (76-82%) dan sesak napas (31-55%). Dari telaah terhadap studi yang ada didapatkan bahwa sampai saat ini Remdesivir adalah obat yang paling berpotensi efektif terhadap Covid-19, walaupun begitu, masih dibutuhkan penelitian lebih lanjut dengan melakukan uji klinis yang lebih luas. Kata kunci: Patogenesis, Manifestasi klinis, Terapi, COVID-19 ABSTRACT Coronavirus Disease 2019 (COVID-19) was discovered at the end of 2019 to be precise in December in Wuhan City, Huebei Province, China and then spread to almost all over the world. Covid-19 is caused by a new type of betacoronavirus which tends to resemble SARS-CoV and MERS-CoV. The purpose of this paper is to provide an analysis of the pathophysiology, clinical manifestations, and development of research on the management of Covid-19. The type of review used in this article is in the form of a literature review of 41 Covid-19 articles using the PubMed and Google Scholar databases. Covid-19 is included in the genus betacoronavirus, the results of anasilis show similarities to SARS. Common symptoms at the onset of illness are fever, fatigue or myalgia, dry cough. As well as several organs involved such as respiratory, gastrointestinal, and neurological. To date, WHO and several countries are conducting clinical trials to find the right drug for Covid-19, this study is called SOLIDARITY. There were 4 groups in this study, namely the LPV / r group and Interferon-beta, Remdesivir, Chloroquine and Hydroxychloroquine. Viral factors with immune response determine the severity of Covid-19 infection. Common symptoms at the onset of illness are fever (83-98%), fatigue or myalgia, dry cough (76-82%) and shortness of breath (31-55%). From a review of existing studies, it is found that to date Remdesivir is the drug with the most potential to be effective against Covid-19, however, further research is still needed by conducting more extensive clinical trials. Keywords: Pathogenesis, Clinical Manifestations, Therapeutic, COVID-19

        Item Type: Article
        Subjects: R Medicine > R Medicine (General)
        Divisions: Jurnal > Fakultas Kedokteran
        Depositing User: Yelvi Levani Levani
        Date Deposited: 06 Apr 2021 20:46
        Last Modified: 09 Jun 2021 11:47
        URI: http://repository.um-surabaya.ac.id/id/eprint/5123

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