Anas, Muhammad and Samsulhadi, Samsulhadi
(2006)
Angka Kejadian Kehamilan Pada Penderita Infertil Dengan Endometriosis Minimal Ringan Yang Mendapatkan Terapi Medroksi Progesteron Asetat Oral
Di RSUD Dr Sutomo Surabaya Indonesia.
Majalah Obstetri Ginekologi, 14 (1).
pp. 29-39.
ISSN 0854-0381
Abstract
Objective : To prove that oral medroxyprogesterone acetate (MPA) can increase pregnancy
rate in infertility couple with minimal and mild endometriotic
Setting : Infertility Outpatien Unit in Dr. Sutomo Hospital Surabava
Material and Methods : Retrospective cohort of infertility couple with minimal and mild endometriotic is selected by eligible criteria divided into two cohort (respectively twenty seven in MPA group and fourty in expectative group). The MPA group were treated by oral medroxyprogesterone acetate 30 - 50 mg between 3 - 6 month and corrected other infertility factors, whereas in expectative group were corrected other infertility factors without given oral medroxyprogesterone acetate. Both group followed until December 31" 2001 to look the pregnancy rate and the difference period between the last therapy or the time of diagnose until pregnancy occurred.
Result : Pregnancy rate of minimal and mild endometriotic patient that managed by oral medroxyprogesterone acetate and expectative was 37.04 % and 50,0 %, with no significant difference between group. The time to pregnancy alter the last oral inedroxyprogesterone acetate was 17,3 ± 9,262 month and 14,9 ± 14.524 month after the time of diagnose in expectative management with no significant difference between group. And in hazard model, the curve of pregnancy occurred in medroxyprogesterone acetate group was belovc of expectative management with no significant difference between group.
Conclusion : Oral medroxyprogesterone acetate is not better than expectative management in treating minimal and mild endornetriotic patient associated infertility.
Key words : Infertility, endometriotic minimal mild, oral MPA, expectative, pregnancy.
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