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Analysis of risks of gastric cancer by gastric mucosa among Indonesian ethnic groups

Miftahussurur, Muhammad and Waskito, Langgeng Agung and Syam , Ari Fahrial and Nusi , Iswan Abbas and Wibawa, I Dewa Nyoman and Rezkitha, Yudith Annisa Ayu and Siregar, Gontar and Yulizal , OK and Akil , Fardah and Uwan, Willy Brodus and Simanjuntak, David and Waleleng, Jimmy Bradley and Saudale, Alexander Michael Joseph and Yusuf , Fauzi and Maulahela , Hasan and Richardo, Marselino and Rahman, Abdul and Namara , Yoma Sari and Sudarmo, Eko and Adi, Pangestu and Maimunah, Ummi and Setiawan, Poernomo Boedi and Fauzia , Kartika Afrida and Doohan , Dalla and Uchida, Tomohisa and Lusida, Maria Inge and Yamaoka , Yoshio (2019) Analysis of risks of gastric cancer by gastric mucosa among Indonesian ethnic groups. PLoS ONE, 14 (5). pp. 1-19. ISSN 1932-6203

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Indonesia is a big country with multiethnic populations whose gastric cancer risks have not been elucidated. We performed a nationwide survey and obtained histological specimens from 1053 individuals in 19 cities across the country. We examined the gastric mucosa, the topography, the atrophic gastritis risk factors, and the gastric cancer risk scores. Almost half (46.1%) of the patients with dyspeptic symptoms had histological abnormalities; chronic (36.3%) and atrophic gastritis (28.9%) being the most frequent. Individuals of the Timor eth- nicity had the highest prevalence of acute (52.6%) and chronic gastritis (68.4%), even those negative for H. pylori. Our topographic analysis showed the majority of patients had predom- inantly antral acute and chronic gastritis. A multivariate logistic regression model showed age (Odds ratio [OR], 1.107), Timor ethnicity (OR, 8.531), and H. pylori infection (OR, 22.643) as independent risk factors for presence of atrophic gastritis. In addition, the gastric cancer risk score was highest in those from Timor, Papuan, and Bugis ethnic populations. Overall, Indonesia is a low-risk gastric cancer country. However, several ethnic groups dis- played severe gastric mucosa symptoms suggesting policy makers should focus on those ethnic groups to perform gastric cancer screenings and to eradicate H. pylori.

Item Type: Article
Uncontrolled Keywords: Risk, gastric cancer, gastric mucosa, ethnic
Subjects: R Medicine > R Medicine (General)
Divisions: Jurnal > Fakultas Kedokteran
Date Deposited: 14 Aug 2020 12:42
Last Modified: 18 Nov 2020 10:43

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