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Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations

Miftahussurur , Muhammad and Waskito, Langgeng Agung and Aftab, Hafeza and Vilaichone, Ratha- korn and Subsomwong, Phawinee and Nusi, Iswan Abbas and Syam, Ari Fahrial and Ratanachu-ek, Thawee and Doohan , Dalla and Siregar, Gontar and Rezkitha, Yudith Annisa Ayu and Fauzia , Kartika Afrida and Mahachai , Varocha and Yamaoka, Yoshio (2020) Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations. PLoS ONE, 15 (4). pp. 1-17. ISSN 1932-6203

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Serum pepsinogens have been widely acknowledged as gastric mucosal biomarkers; how- ever, a multicountry report on the benefits of pepsinogens as biomarkers has not yet been published. We analyzed 1,206 sera and gastric mucosal samples collected from Bangla- desh, Bhutan, Indonesia, Myanmar, Nepal and Thailand then assessed the association between gastric mucosal changes and Helicobacter pylori infection. The new cutoff values for serum pepsinogen values were evaluated using a receiver operating characteristic anal- ysis. The participants with H. pylori infection had significantly lower pepsinogen I and higher pepsinogen II values, but a lower pepsinogen I/II ratio than participants without the infection (all P < .001). The pepsinogen I and pepsinogen I/II values were significantly higher and lower, respectively, in individuals with atrophic gastritis than in those without (both P < .001). Among uninfected individuals, only the pepsinogen I/II ratio was significantly lower in atro- phic individuals. Pepsinogen I/II ratio also were significantly different between disease among H. pylori-positive and H. pylori-negative individuals, suggesting the pepsinogen I/II ratio is a robust biomarker for determining both chronic and atrophic gastritis. The cutoffs for detecting chronic and atrophic gastritis for the pepsinogen I/II ratio were 4.65 and 4.95, respectively. In conclusion, pepsinogen levels are useful biomarker for both chronic gastritis and atrophic gastritis, but they should be used with caution. Population-based validation is necessary to determine the best cutoff values. Among all pepsinogen values, the pepsino- gen I/II ratio was the most reliable gastric mucosal-change biomarker.

Item Type: Article
Uncontrolled Keywords: Pepsinogen, gastric cancer, gastritis, biomaker
Subjects: R Medicine > R Medicine (General)
Divisions: Jurnal > Fakultas Kedokteran
Date Deposited: 14 Aug 2020 13:17
Last Modified: 18 Nov 2020 10:41

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