Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence?

Miftahussurur, Muhammad and Waskito, Langgeng Agung and Fauzia, Kartika Afrida and Mahmudah, Isna and Doohan, Dalla and Adnyana, I Ketut and Khomsan, Ali and Ratnasari, Neneng and Rezkitha, Yudith Annisa Ayu (2020) Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? Gut and Liver, 14. pp. 1-12. ISSN 1976-2283, 2005-1212

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Abstract

Helicobacter pylori infects more than half the human popula- tion. However, the prevalence in Indonesia is low, as is the prevalence of gastric cancer. Hence, it could be instructive to compare these prevalence rates and their determining factors with those of countries that have high gastric can- cer incidence. Ethnicity and genetic characteristics of H. pylori are important determinants of the H. pylori infection rate in Indonesia. The infection rate is higher in Bataknese, Papuans and Buginese than in Javanese, the predominant ethnic group. Ethnicity is also an important determinant of the genetic characteristics of H. pylori . Analysis of CagA in the EPIYA segment showed that the predominant genotypes in Papuans, Bataknese and Buginese are ABB-, ABD- and ABC-type CagA, respectively. Meanwhile, in the countries with high gastric cancer incidence, almost all strains had East Asian type CagA. An antibiotic susceptibility evaluation showed that the standard triple therapy can still be used with caution in several cities. There is a very high rate of resistance to second-line regimens such as levofloxacin and metronidazole. Recent studies have shown that furazolidone, rifabutin and sitafloxacin are potential alternative treatments for antibiotic-resistant H. pylori infection in Indonesia. Rather than focusing on early detection and eradication as in coun- tries with high gastric cancer prevalence, countries with low gastric cancer prevalence should focus on screening the sev- eral groups that have a high risk of gastric cancer.

Item Type:	Article
Uncontrolled Keywords:	Helicobacter pylori ; Indonesia; Prevalence; Virulence, Gastric cancer risk
Subjects:	Q Science > QR Microbiology R Medicine > R Medicine (General)
Divisions:	Jurnal > Fakultas Kedokteran
Depositing User:	YUDITH ANNISA AYU REZKITHA
Date Deposited:	14 Aug 2020 13:51
Last Modified:	18 Nov 2020 10:09
URI:	http://repository.um-surabaya.ac.id/id/eprint/4233

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