Impact of xylene exposure on blood profiles and neurotoxic symptoms among printing workers in Surabaya

Abdul Rohim, Tualeka and Velu Perumal, Perumal and Salsabila, Novianti and Gurendro, Putro and Aceng, Ruyani and Dina Keumala, Sari and Dimas Rahadian Aji, Muhammad and Dewi, Rokhmah and Nur Mukarromah, SKM, M.Kes and Tri Niswati, Utami and Rizky Rahadian, Wicaksono and Rachmy Rosyida, Rois and Ellyza Setya, Maryiantari and Susmiati, Susmiati and Aris, Santjaka and Suardi, Zurimi and Hairudin, Rasako and Mintje Maria, Nendissa and Nurmianto, Eko and Pipid Ari, Wibowo and Ikhram, Hardi S and Rizaldy Fathur, Rachman and Umi, Salmah and Roy Januardi, Irawan and Sunardi, Sunardi and Rizky, Maharja and Aisy, Rahmania and Kurnia Ardiansyah, Akbar and Farhana Syahrotun, Nisa S. and Jihan, Faradisha and Iswari, Hariastuti and Bachtiar, Chahyadhi and Lukman, Handoko (2025) Impact of xylene exposure on blood profiles and neurotoxic symptoms among printing workers in Surabaya. Journal of Medicinal and Pharmaceutical Chemistry Research, 7 (8). pp. 1763-1773. ISSN Print ISSN (p-ISSN): 2981-0213

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Abstract

Xylene exposure is influenced by worker characteristics and the quality of the work environment. This study aimed to investigate the relationship between xylene exposure, blood profiles, and neurotoxic complaints among printing workers in Surabaya. An observational, cross-sectional design was employed, involving 30 workers who met the inclusion criteria. Data collection methods included questionnaires, documentation, interviews, and measurements. The independent variables were the concentration of xylene in the work environment (used to assess the intake dose) and worker characteristics such as age, years of service, working hours, nutritional status, use of personal protective equipment (PPE), smoking habits, and exercise habits. The dependent variables included blood profiles (erythrocytes, platelets, leukocytes, LDL, and cholesterol) and neurotoxic complaints. The results revealed that xylene concentrations were still below the threshold limit value. A total of 16 workers (53.3%) reported experiencing neurotoxic complaints. Blood profiles (erythrocytes, platelets, leukocytes, LDL, and cholesterol) remained within the normal range. Statistically significant relationships were found between xylene intake dose and neurotoxic complaints, between xylene intake dose and blood profiles, and between worker characteristics and neurotoxic complaints. To mitigate risks, it is recommended that printing companies improve ventilation systems, ensure safe working environments, promote a culture of health and safety, conduct regular health checks, and provide appropriate PPE for workers.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Jurnal > Fakultas Ilmu Kesehatan
Depositing User:	NUR MUKARROMAH MUKARROMAH
Date Deposited:	16 Apr 2025 02:27
Last Modified:	16 Apr 2025 02:27
URI:	http://repository.um-surabaya.ac.id/id/eprint/10109

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