The Role of JAK2 in Myeloproliferative Diseases Diagnosis

Rezkitha, Yudith Annisa Ayu and Bintoro, S. Ugroseno Yudho and Ashariati, Ami (2018) The Role of JAK2 in Myeloproliferative Diseases Diagnosis. Biomolecular and health science journal , 1 (2). pp. 135-140. ISSN 2620-8636

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Abstract

Janus Kinase 2 (JAK2) plays an important role in mediating transduction signal of hematopoiesis, including in the pathogenesis of Myeloproliferative diseases (MPD). Various studies have been carried out to identify the position of aleles in tyrosine encoding mutations. Although the effect of JAK2 mutations is still not fully understood, the discovery of these mutations might be able to differentiate the types of polycythaemia vera, essential thrombocytemia, and primary myelofibrosis with malignant abnormalities. WHO has revised the MPD diagnosis criteria following this finding. This review will discuss the role of JAK2.

Item Type:	Article
Uncontrolled Keywords:	Janus Kinase 2, Myeloproliferative disease, Mutation
Subjects:	R Medicine > R Medicine (General)
Divisions:	Jurnal > Fakultas Kedokteran
Depositing User:	YUDITH ANNISA AYU REZKITHA
Date Deposited:	14 Aug 2020 14:26
Last Modified:	18 Nov 2020 09:55
URI:	http://repository.um-surabaya.ac.id/id/eprint/4236

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