Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence

Miftahussurur , Muhammad and Doohan, Dalla and Nusi, Iswan Abbas and Adi, Pangestu and Rezkitha , Yudith Annisa Ayu and Waskito, Langgeng Agung and Fauzia, Kartika Afrida and Bramantoro, Taufan and Maimunah, Ummi and Thamrin , Husin and Masithah, Safitri Indah and Sukadiono, Sukadiono and Uchida, Tomohisa and Lusida, Maria Inge and Yamaoka, Yoshio (2018) Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence. PLoS ONE, 13 (11). pp. 1-15. ISSN 1932-6203

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Abstract

The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We ana- lyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. We recruited 104 dyspeptic patients who underwent endoscopy in Surabaya. Patients were diagnosed with GERD based on the Los Angeles classification. We evaluated gastric biopsy specimens and measured serum pepsinogen levels. Interleu- kin polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism. Of 104 patients, 56 (53.8%) were endoscopically found to have GERD, with most categorized as grade A; 48 (46.2%) were classified as non-GERD. Higher economic status, smoking, and a history of proton-pump inhibitor use significantly increased the risk of GERD. GERD Questionnaire scores showed a positive correlation with GERD (P < 0.001). An association was found between antral atrophic gastritis and GERD (P = 0.030), and patients with GERD more frequently had severe antral atrophy than nonerosive reflux dis- ease (P = 0.018). We found an association between pepsinogen I/II levels and GERD (P = 0.047), but with low accuracy. IL-1β -511 TT and CT were predominant among the IL- 1β -511 genotypes, and IL-8–251 AT and TT were predominant among the IL-8–251 geno- types. In conclusion, we found a high prevalence of GERD in an area with low prevalence of H. pylori infection, which could be associated with acid reflux. Smoking, history of proton- pump inhibitor use, and higher economic group significantly increased the risk of GERD.

Item Type:	Article
Uncontrolled Keywords:	GERD, Helicobacter pylori, infection
Subjects:	Q Science > QR Microbiology R Medicine > R Medicine (General)
Divisions:	Jurnal > Fakultas Kedokteran
Depositing User:	YUDITH ANNISA AYU REZKITHA
Date Deposited:	14 Aug 2020 12:37
Last Modified:	18 Nov 2020 10:50
URI:	http://repository.um-surabaya.ac.id/id/eprint/4223

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