Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests

Miftahussurur, Muhammad and Shiota, Seiji and Suzuki, Rumiko and Matsuda, Miyuki and Uchida, Tomohisa and Kido, Yasutoshi and Kawamoto, Fumihiko and Maimunah, Ummi and Adi , Pangestu and Rezkitha, Yudith Annisa Ayu and Nasronudin, Nasronudin and Nusi, Iswan Abbas and Yamaoka, Yoshio (2014) Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests. Epidemiology and Infection, 143 (5). pp. 986-996. ISSN 1469-4409, 0950-2688

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Abstract

The prevalence of Helicobacter pylori infection in Indonesia is controversial. We examined the H. pylori infection rate in 78 patients in a hospital in Surabaya using five different tests, including culture, histology, immunohistochemistry, rapid urease test, and urine antibody test. Furthermore, we analysed virulence factors in H. pylori strains from Indonesia. The H. pylori infection rate was only 11·5% in all patients studied, and 2·3% of Javanese patients and 18·0% of Chinese patients were infected (P=0·01). Although severe gastritis was not observed, activity and inflammation were significantly higher in patients positive for H. pylori than in patients negative for H. pylori. Among genotypes identified from five isolated strains, cagA was found in four; two were vacA s1m1. All cagA-positive strains were oipA ‘on’ and iceA1 positive. We confirmed both a low H. pylori infection rate and a low prevalence of precancerous lesions in dyspeptic patients in a Surabaya hospital, which may contribute to the low incidence of gastric cancer in Indonesia.

Item Type:	Article
Uncontrolled Keywords:	Helicobacter pylori, Indonesia, virulence factors
Subjects:	Q Science > QR Microbiology R Medicine > R Medicine (General)
Divisions:	Jurnal > Fakultas Kedokteran
Depositing User:	YUDITH ANNISA AYU REZKITHA
Date Deposited:	14 Aug 2020 11:16
Last Modified:	18 Nov 2020 11:07
URI:	http://repository.um-surabaya.ac.id/id/eprint/4239

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