SAMSUDIN, RINZA RAHMAWATI and Kunsah, Baterun and Widyastuti, Rahma
(2017)
Pengaruh Pemberian Ekstrak Bunga Sepatu (Hibiscus rosa-sinensis L.) Terhadap Darah
Mencit (Mus musculus) Yang Mengalami Hiperkolesterolemia.
Universitas Muhammadiyah surabaya.
Abstract
INTRODUCTION Dyslipidemia is a lipid metabolism disorder characterized by the increasing
TC, LDL cholesterol, triacylglycerol TG above normal values and decrease of HDL in the blood.
Increasing LDL-C and triacylglycerol have a correlation with poor cardiovascular circumstances
and increased lipid absorption may lead to conditions of dyslipidemia. Orange peel is often
considered a waste that is not useful. The purpose of this study wanted to know the effect of
giving orange peel to the mice dyslipidemia. METHOD This study was an experimental study,
using a randomized post test only control group design using twenty-seven white rats (Rattus
norvegicus) Wistar strains. This study lasted for eight weeks. Mice dyslipidemia is made by
giving high fat feed to all groups of K1, K2 and K3. Each group consists of 9 white rats divided
randomly. The composition of high-fat feed is a modification of the formula Nutrient
requirements of laboratory animals. RESULTS The mean of body weight of K1, K2 and K3
groups tended to increase. Increased body weight of mice began to occur at week 2, after the K1,
K2, and K3 groups were given a high-fat diet. Levels of TC, LDL-C and TG in K2 and K3 group
treated with sweet peel leaf extract of pacitan with dosage of CMC-Na 1% dose 500 mg / kg BW
and CMC-Na 1% dose 750 mg / kg BW Lower than the K1 group. Decreased levels of TC, LDLC and TG occurring in groups of K2 and K3 significantly. DISCUSSION. The compound dlimonene of Pacitanese orange may affect PPAR. PPAR (Peroxisome proliferator-activated
receptors) is a transcription factor of super family nuclear receptors. PPAR circulating with its
ligand may affect lipid metabolism The compound d-limonene of Pacitanese orange may
activiting PPAR. Activating PPAR can affect the total cholesterol levels in the blood. The
mechanism of PPAR in affecting total cholesterol is by inhibiting NPC1L1 activity in the
intestinal wall. NP1C1 is a transporter in charge of bringing cholesterol into the blood. The
decrease of LDL-C level may occur due to hesperidin content in the peel of Pacitanese sweet
orange where the mechanism of action of hesperidin is estimated by inhibition of reductase
HMGCoA enzyme activity
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