Hubungan antara Kadar Serum Hepcidin dengan Tinggi Badan dan Berat Badan pada Pasien Talasemia Beta Mayor di RS Universitas Airlangga

Pendahuluan: Talasemia Beta Mayor merupakan kelainan darah herediter yang memerlukan transfusi darah secara rutin, sehingga menyebabkan penumpukan zat besi kronis dalam tubuh. Hepcidin merupakan hormon yang diproduksi oleh hati dan berperan dalam mengatur homeostasis besi melalui kontrol terhadap penyerapan dan distribusi besi. Pada pasien Talasemia Beta Mayor, kadar hepcidin cenderung menurun akibat eritropoiesis yang tidak efektif sehingga berkontribusi terhadap terjadinya kelebihan zat besi yang progresif dan dapat menyebabkan disfungsi endokrin serta gangguan pertumbuhan, termasuk tinggi badan dan berat badan. Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara kadar serum hepcidin dengan tinggi badan dan berat badan pada pasien Talasemia Beta Mayor di RS Universitas Airlangga. Metode: Penelitian ini menggunakan desain cross-sectional dengan teknik consecutive sampling pada 36 pasien berusia 18–45 tahun. Kadar serum hepcidin diukur menggunakan metode ELISA, sedangkan tinggi dan berat badan diukur secara antropometri. Hasil: Hasil penelitian menunjukkan rerata kadar hepcidin sebesar 4,467 ± 0,128 ng/mL, tinggi badan 153,94 ± 10,43 cm, dan berat badan 45,5 ± 8,96 kg. Uji korelasi Pearson menunjukkan nilai koefisien korelasi antara kadar serum hepcidin dengan tinggi badan sebesar r = -0,183 dan p = 0,285, sedangkan dengan berat badan sebesar r = -0,194 dan p = 0,258. Kesimpulan: Tidak terdapat hubungan yang signifikan antara kadar serum hepcidin dengan tinggi badan maupun berat badan pada pasien Talasemia Beta Mayor di RS Universitas Airlangga.

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Introduction: Beta Thalassemia Major is a hereditary blood disorder requiring regular blood transfusions and leading to chronic iron overload. Hepcidin is a peptide hormone produced by the liver, plays a key role in regulating iron homeostasis by controlling iron absorption and distribution. In patients with Beta Thalassemia Major, hepcidin levels are often suppressed due to ineffective erythropoiesis, resulting in progressive iron accumulation that may cause endocrine dysfunction and impair physical growth, including height and body weight. Objective: This study aimed to analyzed the relationship between serum hepcidin levels and height and body weight in Beta Thalassemia Major Patients at Airlangga University Hospital. Methods: A cross-sectional design with consecutive sampling was used, involving 36 adult patients aged 18–45 years. Serum hepcidin levels were measured using the ELISA method, while height and body weight were assessed anthropometrically. Data were analyzed using Pearson correlation test. Results: The mean serum hepcidin level was 4.467 ± 0.128 ng/mL, mean height was 153.94 ± 10.43 cm, and mean body weight was 45.5 ± 8.96 kg. Pearson correlation analysis showed correlation coefficients of r = -0.183 (p = 0.285) between serum hepcidin levels and height and r = -0.194 (p = 0.258) between serum hepcidin levels and body weight. Conclusions: In conclusion, there was no significant relationship between serum hepcidin levels and either height or body weight in patients with Beta Thalassemia Major.