Hubungan antara Kadar LDL dengan Kadar High Sensitivity Troponin I pada Kasus Infark Miokard di RS Siti Khodijah Sepanjang

Pendahuluan: Infark miokard merupakan kerusakan pada sel otot jantung akibat berkurangnya suplai oksigen ke jaringan jantung karena penyempitan arteri, yang dapat berujung pada penyumbatan total atau parsial pada arteri. Low Density Lipoprotein (LDL) diketahui sebagai salah satu faktor risiko infark miokard. Kadar LDL yang meningkat pada pembuluh darah menyebabkan terjadinya disfungsi endotel sehingga memicu terbentuknya plak aterosklerosis. Kerusakan pada miokard dapat dideteksi dengan kadar Hs-Troponin I yang meningkat di darah, akibat permeabilitas membran sel miokard meningkat sehingga banyak komponen intrasel yang merembes termasuk troponin I.
Tujuan: Menganalisis hubungan antara kadar LDL dengan kadar Hs-Troponin I pada pasien infark miokard di RS Siti Khodijah Sepanjang.
Metode: Penelitian ini merupakan penelitian kuantitatif dengan desain observasional analitik dengan pendekatan cross sectional. Jumlah sample pada penelitian ini sebanyak 81 pasien Infark Miokard di RS Siti Khodijah Sepanjang yang memenuhi kriteria inklusi dan eksklusi. Data kadar LDL dan kadar Hs-Troponin I menggunakan rekam medis pasien. Penelitian ini menggunakan uji korelasi Spearman.
Hasil: Hasil penelitian ini menunjukkan bahwa terdapat hubungan antara kadar LDL dengan kadar Hs-Troponin I pada pasien infark miokard dengan nilai signifikansi p< 0,05 dan nilai koefisiensi korelasi r = 0,231yang menunjukkan hubungan tersebut bernilai positif dengan kekuatan hubungan lemah.
Kesimpulan : Terdapat hubungan yang signifikan antara antara kadar LDL dengan kadar Hs-Troponin I pada pasien infark miokard di RS Siti Khodijah Sepanjang.

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Introduction: Myocardial infarction is damage to heart muscle cells caused by a reduced supply of oxygen to the heart tissue due to narrowing of the arteries, which can lead to total or partial blockage of the arteries. Low Density Lipoprotein (LDL) is known to be a risk factor for myocardial infarction. Elevated LDL level in the blood vessels cause endothelial dysfunction, thereby triggering the formation of atherosclerotic plaques. Damage to the myocardium can be detected by elevated levels of Hs-Troponin I in the blood, resulting from increased permeability of the myocardial cell membrane, which allows many intracellular components including troponin I to leak out.
Objective: To analyze the relationship between LDL levels and Hs-Troponin I levels in patients with myocardial infarction at Siti Khodijah Sepanjang Hospital.
Methods: This study is a quantitative study with an analytical observational design using a cross sectional approach. The sample size consisted of 81 myocardial infarction patients at Siti Khodijah Sepanjang Hospital who met the inclusion and exclusion criteria. Data on LDL levels and Hs-Troponin I levels were obtained from patients’medical records. This study used the Spearman correlation test.
Results: The results of his study indicate that there is a relationship between LDL levels and Hs-Troponin I levels in myocardial infarction patient, with a significance level of p<0,05 and a correlation coefficient of r = 0,231, indicating a positive relationship with a weak strength of association.
Conclusion: There is a significant relationship between LDL levels and Hs-Troponin I levels in myocardial infarction patients at Siti Khodijah Hospital in Sepanjang.