Profil Penggunaan Antiplatelet pada Pasien Jantung Koroner (Penelitian Dilakukan di Rawat Inap RSUD Haji Provinsi Jawa Timur)

Penyakit Jantung Koroner (PJK) merupakan salah satu penyebab utama kematian di dunia dan di Indonesia. Terapi antiplatelet berperan penting dalam mencegah agregasi trombosit dan pembentukan trombus pada pasien PJK. Penelitian ini bertujuan untuk mendeskripsikan profil penggunaan antiplatelet pada pasien PJK di Instalasi Rawat Inap RSUD Haji Provinsi Jawa Timur. Penelitian ini menggunakan desain deskriptif retrospektif dengan sumber data rekam medis pasien periode Januari–Juni 2025. Sampel sebanyak 240 pasien dipilih menggunakan teknik purposive sampling dari total populasi 605 pasien, berdasarkan perhitungan rumus Slovin dengan margin of error 5%. Hasil penelitian menunjukkan bahwa sebagian besar pasien berusia > 65 tahun 81 pasien (34%) dan didominasi laki-laki 130 pasien (54%). Keluhan utama adalah nyeri dada 192 pasien (80%) dengan komorbid terbanyak hipertensi 119 pasien (50%). Diagnosis yang paling sering ditegakkan adalah Unstable Angina Pectoris (UAP) 156 pasien (65%) dan lama rawat inap sebagian besar ≤ 7 hari 231 pasien (96%). Terapi tunggal klopidogrel 75 mg 96 pasien (40%) merupakan regimen yang paling banyak digunakan. Perubahan regimentasi yang paling sering ditemukan adalah dari kombinasi asetosal 80 mg dan klopidogrel 75 mg menjadi asetosal 80 mg 5 pasien (20%). Pasien dengan komorbid hipertensi paling banyak terdiagnosis UAP dan mendapatkan terapi klopidogrel 37 pasien (54%).= Coronary heart disease (CHD) is one of the leading causes of death worldwide and in Indonesia. Antiplatelet therapy plays an important role in preventing platelet aggregation and thrombus formation in CHD patients. Objective: This study aims to describe the profile of antiplatelet use in CHD patients at the Inpatient Unit of the East Java Provincial Haji Hospital. This study used a retrospective descriptive design with data sourced from patient medical records from January to June 2025. A sample of 240 patients was selected using purposive sampling from a total population of 605 patients, based on the Slovin formula with a margin of error 5%. The results of the study show that most patients were aged >65 years 81 patients (34%) and were predominantly male 130 patients (54%). The main complaint was chest pain 192 patients (80%), with the most common comorbidity being hypertension 119 patients (50%). The most common diagnosis was UAP in 156 patients (65%), and the majority of hospital stays were ≤7 days in 231 patients (96%). Single therapy with clopidogrel 75 mg in 96 patients (40%) was the most commonly used regimen. The most common change in medication regimen was from a combination of 80 mg of acetylsalicylic acid and 75 mg of clopidogrel to 80 mg of acetylsalicylic acid in 5 patients (20%). Patients with hypertension as the most common comorbidity were most frequently diagnosed with UAP and received clopidogrel therapy in 37 patients (54%).

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Coronary heart disease (CHD) is one of the leading causes of death worldwide and in Indonesia. Antiplatelet therapy plays an important role in preventing platelet aggregation and thrombus formation in CHD patients. Objective: This study aims to describe the profile of antiplatelet use in CHD patients at the Inpatient Unit of the East Java Provincial Haji Hospital. This study used a retrospective descriptive design with data sourced from patient medical records from January to June 2025. A sample of 240 patients was selected using purposive sampling from a total population of 605 patients, based on the Slovin formula with a margin of error 5%. The results of the study show that most patients were aged >65 years 81 patients (34%) and were predominantly male 130 patients (54%). The main complaint was chest pain 192 patients (80%), with the most common comorbidity being hypertension 119 patients (50%). The most common diagnosis was UAP in 156 patients (65%), and the majority of hospital stays were ≤7 days in 231 patients (96%). Single therapy with clopidogrel 75 mg in 96 patients (40%) was the most commonly used regimen. The most common change in medication regimen was from a combination of 80 mg of acetylsalicylic acid and 75 mg of clopidogrel to 80 mg of acetylsalicylic acid in 5 patients (20%). Patients with hypertension as the most common comorbidity were most frequently diagnosed with UAP and received clopidogrel therapy in 37 patients (54%).