Hubungan antara Kadar LDL dengan Tingkat Keparahan Stroke Iskemik di Rumah Sakit Bhayangkara Surabaya

Stroke iskemik hingga saat ini tetap termasuk salah satu penyebab terbesar gangguan neurologis dan mortalitas di berbagai negara. Dislipidemia, khususnya peningkatan kadar low density lipoprotein (LDL), diketahui berperan dalam pembentukan aterosklerosis yang dapat memperburuk manifestasi klinis pada pasien stroke. Penelitian ini dilakukan untuk mengetahui hubungan antara kadar low density lipoprotein (LDL) dengan tingkat keparahan stroke iskemik di Rumah Sakit Bhayangkara Surabaya. Metode yang digunakan dalam penelitian adalah analitik observasional dengan pendekatan cross-sectional terhadap 45 pasien stroke iskemik rawat inap. Data kadar LDL diperoleh melalui rekam medis pasien, sedangkan penilaian skor tingkat keparahan stroke menggunakan instrumen National Institutes of Health Stroke Scale (NIHSS). Hubungan antara kadar LDL dan tingkat keparahan stroke dianalisis menggunakan uji korelasi Spearman. Hasil penelitian memperlihatkan bahwa dominasi pasien dengan kadar LDL dalam kategori borderline high sebanyak 15 pasien (33,3%), dan derajat keparahan stroke terbanyak berada pada kategori moderate stroke sebanyak 21 pasien (46,7%). Berdasarkan hasil uji statistik, didapatkan hubungan positif yang kuat dan signifikan antara kadar LDL dengan tingkat keparahan stroke iskemik (r = 0,704; p < 0,001). Semakin tinggi kadar LDL, semakin berat defisit neurologis yang dialami pasien stroke iskemik. Penelitian ini menegaskan bahwa pengendalian kadar LDL penting dilakukan sebagai bagian dari upaya pencegahan dan tata laksana stroke iskemik untuk mengurangi risiko perburukan neurologis.

=================================================================================

Ischemic stroke remains one of the leading causes of neurological impairment and mortality worldwide. Dyslipidemia, particularly elevated levels of low-density lipoprotein (LDL), is known to contribute to the development of atherosclerosis that may worsen the clinical manifestations in stroke patients. This study aimed to determine the relationship between low-density lipoprotein (LDL) levels and the severity of ischemic stroke at Bhayangkara Hospital Surabaya. This research used an analytic observational method with a cross-sectional approach involving 45 hospitalized ischemic stroke patients. LDL level data were obtained from patients’ medical records, while stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). The relationship between LDL levels and stroke severity was analyzed using the Spearman correlation test. The results showed that most patients had LDL levels in the borderline high category, accounting for 15 patients (33.3%), while the majority of stroke severity was classified as moderate stroke in 21 patients (46.7%). Statistical analysis demonstrated a strong and significant positive correlation between LDL levels and ischemic stroke severity (r = 0.704; p < 0.001). Higher LDL levels were associated with more severe neurological deficits in ischemic stroke patients. This study emphasizes that controlling LDL levels is important as part of prevention and management strategies for ischemic stroke to reduce the risk of neurological deterioration.