Hubungan Diabetes Melitus dengan Kejadian Multivessle Disease pada Pasien Sindrom Koroner Akut di RS Siti Khodijah Muhammadiyah Cabang Sepanjang

Herman, Athayya Raissa Insyira (2026) Hubungan Diabetes Melitus dengan Kejadian Multivessle Disease pada Pasien Sindrom Koroner Akut di RS Siti Khodijah Muhammadiyah Cabang Sepanjang. Undergraduate thesis, Universitas Muhammadiyah Surabaya.

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Abstract

Latar belakang: Sindrom Koroner Akut (SKA) masih menjadi salah satu penyebab utama tingginya angka kesakitan dan kematian akibat penyakit kardiovaskular. Diabetes Mellitus (DM) diketahui berperan dalam mempercepat perkembangan aterosklerosis melalui berbagai mekanisme, seperti hiperglikemia kronis, gangguan fungsi endotel, proses inflamasi vaskular, dan pembentukan plak aterosklerotik yang lebih luas, sehingga meningkatkan risiko keterlibatan lebih dari satu pembuluh darah koroner atau Multivessel Disease (MVD).
Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara Diabetes Mellitus dan kejadian Multivessel Disease pada pasien SKA di RS Siti Khodijah Muhammadiyah Cabang Sepanjang.
Metode: Penelitian dilakukan dengan metode observasional analitik menggunakan rancangan cross-sectional dan memanfaatkan data sekunder yang bersumber dari rekam medis pasien SKA yang telah menjalani angiografi koroner.
Hasil: Hasil penelitian menunjukkan bahwa proporsi kejadian Multivessel Disease lebih tinggi pada kelompok pasien dengan Diabetes Mellitus (62,9%) dibandingkan kelompok tanpa Diabetes Mellitus (19,4%). Analisis statistik menunjukkan adanya hubungan yang bermakna antara DM dan kejadian Multivessel Disease pada pasien SKA (P < 0,001).
Kesimpulan: Temuan ini menunjukkan bahwa pasien SKA dengan DM cenderung mengalami distribusi keterlibatan arteri koroner yang lebih luas dibandingkan pasien tanpa DM. Oleh karena itu, hasil penelitian ini diharapkan dapat menjadi bahan pertimbangan bagi klinisi dalam mengidentifikasi pasien SKA yang memiliki risiko lebih tinggi terhadap lesi koroner yang ekstensif, sehingga strategi diagnosis, penatalaksanaan, dan perencanaan revaskularisasi dapat dilakukan secara tepat.

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Introduction: Acute Coronary Syndrome (ACS) remains one of the leading causes of morbidity and mortality associated with cardiovascular diseases. Diabetes Mellitus (DM) plays a significant role in accelerating the progression of atherosclerosis through several mechanisms, including chronic hyperglycemia, endothelial dysfunction, vascular inflammation, and the formation of more extensive atherosclerotic plaques, thereby increasing the risk of Multivessel Disease (MVD). Objective: This study aimed to analyze the association between Diabetes Mellitus and the incidence of Multivessel Disease among patients with Acute Coronary Syndrome at Siti Khodijah Muhammadiyah Hospital, Sepanjang.
Methods: An analytical observational study with a cross-sectional design was conducted using secondary data obtained from the medical records of ACS patients who had undergone coronary angiography.
Result: The results showed that the proportion of Multivessel Disease was higher among patients with Diabetes Mellitus (62.9%) compared to those without Diabetes Mellitus (19.4%). Statistical analysis revealed a significant association between Diabetes Mellitus and the incidence of Multivessel Disease in ACS patients (p < 0.001).
Conclusion: These findings indicate that ACS patients with Diabetes Mellitus tend to have more distribution extensive coronary artery involvement than those without Diabetes Mellitus. Therefore, this study is expected to provide valuable information for clinicians in identifying ACS patients who are at a higher risk of developing extensive coronary lesions, thereby facilitating appropriate diagnostic strategies, patient management, and revascularization planning.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Diabetes Mellitus , Sindrom Koroner Akut, Multivessle Disease , Angiografi Koroner, Diabetes Mellitus, Acute Coronary Syndrome, Multivessel Disease, CoronaryAngiography
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: 05. Fakultas Kedokteran > Pendidikan Dokter
Depositing User: ATHAYYA RAISSA INSYIRA HERMAN
Date Deposited: 07 Jul 2026 01:16
Last Modified: 07 Jul 2026 01:19
URI: https://repository.um-surabaya.ac.id/id/eprint/12709

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