Hubungan antara Limfosit dan Monosit Absolut dengan Hasil Sputum Tes Cepat Molekuler Tuberkulosis Paru di RS Siti Khodijah Muhammadiyah Sepanjang

Latar Belakang: Latar Belakang: Tuberkulosis (TB) merupakan penyakit infeksi yang masih menjadi masalah kesehatan masyarakat di Indonesia. Limfosit dan monosit merupakan sel imun yang berperan dalam respons tubuh terhadap infeksi Mycobacterium tuberculosis sehingga diduga berhubungan dengan hasil pemeriksaan Tes Cepat Molekuler (TCM).
Tujuan: Menganalisis hubungan limfosit absolut dan monosit absolut dengan hasil pemeriksaan Tes Cepat Molekuler (TCM) tuberkulosis paru.
Metode: Penelitian analitik observasional dengan desain cross-sectional menggunakan teknik total sampling terhadap 77 pasien di RS Siti Khodijah Muhammadiyah Cabang Sepanjang. Analisis dilakukan menggunakan regresi logistik biner dengan variabel kontrol usia dan jenis kelamin.
Hasil: Median limfosit absolut adalah 1,43 ×10³/µL (0,27–3,33 ×10³/µL), sedangkan rerata monosit absolut 0,94 ± 0,41 ×10³/µL (0,16–1,73 ×10³/µL). Hasil regresi logistik biner menunjukkan bahwa limfosit absolut berhubungan secara bermakna dengan hasil pemeriksaan TCM (p = 0,006), sedangkan monosit absolut tidak berhubungan secara bermakna (p = 0,141).
Kesimpulan: Terdapat hubungan yang bermakna antara limfosit absolut dengan hasil pemeriksaan TCM tuberkulosis paru, sedangkan monosit absolut tidak menunjukkan hubungan yang bermakna.

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Background: Tuberculosis (TB) remains a major public health problem in Indonesia. Lymphocytes and monocytes are immune cells involved in the host response to Mycobacterium tuberculosis infection and are therefore considered potential indicators associated with the results of the Molecular Rapid Test (MRT). Objective: To analyze the association between absolute lymphocyte count and absolute monocyte count with Molecular Rapid Test (MRT) results in patients with pulmonary tuberculosis.
Methods: This analytical observational study employed a cross-sectional design involving 77 patients selected using total sampling at Siti Khodijah Muhammadiyah Hospital, Sepanjang Branch. Data were analyzed using binary logistic regression while controlling for age and sex.
Results: The median absolute lymphocyte count was 1.43 × 10³/µL (0.27–3.33 × 10³/µL), while the mean absolute monocyte count was 0.94 ± 0.41 × 10³/µL (0.16–1.73 × 10³/µL). Binary logistic regression analysis demonstrated a significant association between absolute lymphocyte count and MRT results (p = 0.006). In contrast, no significant association was observed between absolute monocyte count and MRT results (p = 0.141).
Conclusion: Absolute lymphocyte count was significantly associated with Molecular Rapid Test (MRT) results in patients with pulmonary tuberculosis, whereas absolute monocyte count was not significantly associated.