Hubungan antara Gula Darah 2 Jam Post Prandial dengan Kreatinin dan Ureum Pasien Diabetes Melitus Tipe 2 RSI Aisyiyah Malang

Latar Belakang : Diabetes Melitus Tipe 2 (DMT2) merupakan penyakit metabolik kronis yang dapat menyebabkan berbagai komplikasi, termasuk gangguan fungsi ginjal. Pemeriksaan kadar ureum dan kreatinin sering digunakan sebagai indikator fungsi ginjal pada pasien DMT2. Kadar glukosa darah 2 jam postprandial (GD2PP) mencerminkan kontrol glikemik setelah makan dan diduga berhubungan dengan kerusakan ginjal. Tujuan : Menganalisis hubungan kadar GD2PP dengan kadar ureum dan kreatinin pada pasien DMT2 di RSI Aisyiyah Malang. Metode : Penelitian observasional analitik dengan pendekatan cross-sectional menggunakan data rekam medis pasien DMT2 di RSI Aisyiyah Malang. Sampel penelitian berjumlah 125 pasien yang memenuhi kriteria inklusi. Data dianalisis menggunakan uji Chi-square dengan tingkat signifikansi p<0,05. Hasil : Sebagian besar responden berusia 46–65 tahun (96%) dan berjenis kelamin perempuan (63,2%). Kadar kreatinin tinggi ditemukan pada 119 responden (95,2%), sedangkan kadar ureum tinggi ditemukan pada 121 responden (96,8%). Hasil analisis hubungan GD2PP dengan kadar kreatinin menunjukkan nilai p=0,67 dengan OR=1,43, sedangkan hubungan GD2PP dengan kadar ureum menunjukkan nilai p=0,73 dengan OR=1,42. Hasil tersebut menunjukkan tidak terdapat hubungan yang bermakna secara statistik antara kadar GD2PP dengan kadar kreatinin maupun kadar ureum pada pasien DMT2. Kesimpulan : Tidak terdapat hubungan yang signifikan antara kadar GD2PP dengan kadar kreatinin dan kadar ureum pada pasien Diabetes Melitus Tipe 2 di RSI Aisyiyah Malang. Peningkatan kadar ureum dan kreatinin kemungkinan dipengaruhi oleh faktor lain selain kadar glukosa darah postprandial.

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Background : Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder that may lead to various complications, including renal dysfunction. Urea and creatinine levels are commonly used as indicators of kidney function in patients with T2DM. Two-hour postprandial blood glucose (2hPPBG) reflects post-meal glycemic control and is suspected to be associated with renal impairment. Objective : To analyze the relationship between 2hPPBG levels and urea and creatinine levels in patients with T2DM at RSI Aisyiyah Malang. Methods : This analytical observational study employed a cross-sectional approach using medical record data of T2DM patients at RSI Aisyiyah Malang. A total of 125 patients who met the inclusion criteria were included. Data were analyzed using the Chi-square test with a significance level of p<0.05. Results : Most respondents were aged 46–65 years (96%) and female (63.2%). Elevated creatinine levels were found in 119 respondents (95.2%), while elevated urea levels were found in 121 respondents (96.8%). Statistical analysis showed no significant relationship between 2hPPBG and creatinine levels (p=0.67; OR=1.43) and no significant relationship between 2hPPBG and urea levels (p=0.73; OR=1.42). Conclusion : There was no significant relationship between 2hPPBG levels and creatinine or urea levels among patients with Type 2 Diabetes Mellitus at RSI Aisyiyah Malang. Elevated urea and creatinine levels may be influenced by factors other than postprandial blood glucose levels.