Efektivitas High-Protein Nutrition terhadap Kadar Leukosit pada Pasien Tuberculosis di Intensive Unit RSUD Haji Surabaya

Pendahuluan: Tuberculosis merupakan penyakit infeksi kronis yang dapat meningkatkan kadar leukosit sebagai bagian dari respons inflamasi tubuh. Pemenuhan protein yang adekuat diperlukan untuk mendukung fungsi imun dan mempercepat proses pemulihan pasien. Metode: Penelitian ini menggunakan desain pre-eksperimental dengan pendekatan one group pretest-posttest. Sampel penelitian berjumlah 43 pasien tuberculosis dengan nasogastric tube (NGT) yang dirawat di Intensive Unit RSUD Haji Surabaya dan dipilih menggunakan teknik simple random sampling. Kadar leukosit diukur sebelum dan sesudah pemberian High Protein Nutrition selama tiga hari. Analisis data menggunakan uji Wilcoxon Signed Rank Test dengan tingkat signifikansi α=0,05. Hasil: Sebelum intervensi, sebagian besar responden mengalami leukositosis sebanyak 23 responden (53,5%), sedangkan 20 responden (46,5%) memiliki kadar leukosit normal. Setelah pemberian High Protein Nutrition, jumlah responden dengan kadar leukosit normal meningkat menjadi 31 responden (72,1%), sementara leukositosis menurun menjadi 10 responden (23,3%). Hasil uji Wilcoxon menunjukkan nilai p=0,002 (p<0,05), yang menunjukkan adanya perbedaan kadar leukosit yang signifikan sebelum dan sesudah intervensi. Temuan ini menunjukkan bahwa High Protein Nutrition berperan dalam mendukung fungsi imun dan membantu perbaikan respons inflamasi pada pasien Tuberculosis. Pembahasan: High Protein Nutrition efektif terhadap perbaikan kadar leukosit pada pasien Tuberculosis di Intensive Unit RSUD Haji Surabaya.
Kata Kunci: High Protein Nutrition; Intensive Unit; Leukosit; Tuberculosis

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Introduction: Tuberculosis is a chronic infectious disease that can increase leukocyte levels as part of the body’s inflammatory response. Adequate protein intake is required to support immune function and accelerate the recovery process of patients. Methods: This study employed a pre-experimental design with a one-group pretest–posttest approach. The study sample consisted of 43 patients with tuberculosis who had a nasogastric tube (NGT) and were treated in the Intensive Unit of Haji Regional General Hospital, Surabaya. The participants were selected using simple random sampling. Leukocyte levels were measured before and after the administration of High-Protein Nutrition for three days. Data were analyzed using the Wilcoxon signed-rank test with a significance level of α = 0.05. Results: Before the intervention, 23 respondents (53.5%) had leukocytosis, while 20 respondents (46.5%) had normal leukocyte levels. After the administration of High-Protein Nutrition, the number of respondents with normal leukocyte levels increased to 31 (72.1%), while the number with leukocytosis decreased to 10 (23.3%). The Wilcoxon test yielded a p-value of 0.002 (p < 0.05), indicating a significant difference in leukocyte levels before and after the intervention. These findings indicate that High Protein Nutrition plays a role in supporting immune function and helping improve the inflammatory response in patients with tuberculosis. Discussion: High Protein Nutrition was effective in improving leukocyte levels in patients with tuberculosis in the Intensive Unit of Haji Regional General Hospital, Surabaya.
Keywords: High Protein Nutrition; Intensive Unit; Leukocycte; Tuberculosis