Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus)

Bagaskara, Andre and Triastuti, Nenny and Yuliyanasari, Nurma and Rezkitha, Yudith Annisa Ayu and Anas, Muhammad and Alfaray, Ricky Indra (2022) Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus). Magna Medica : Berkala Ilmiah Kedokteran dan Ilmu Kesehatan, 9 (1). pp. 1-9. ISSN e-ISSN: 2774-2318, p-ISSN: 2407-0505

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Abstract

Background: Putri Malu leaf plants (Mimosa pudica Linn) contain flavo noid compounds beneficial as hepatoprotectors. Putri Malu leaf plant extract can be useful to prevent problems such as Ibuprofen-induced he patic damage, but studies that focus on this topic remain scarce in Indo nesia. Objective: To prove the extracted content of the leaves of the Putri Malu plant (Mimosa pudica Linn) as a hepatoprotector of hepatic damage in mice (Mus musculus) induced by Ibuprofen Method: This randomized post-test control group design was conducted at the Experimental Animal Laboratory, Faculty of Veterinary Medicine, Universitas Airlangga. A total of 28 mice were treated with four condi tions then underwent SGOT and SGPT blood laboratory tests. Results: Group P1 (placebo) had SGOT and SGPT levels averaging 23.87 mg/dl and 13.45 mg/dl, group P2 (ibuprofen dose 7 mg/kg BW) had SGOT and SGPT levels of 29.13 mg/dl and 19.10 mg/dl, group 3 (Putri Malu extract 35 mg/kg BW) had SGOT and SGPT of 24.05 mg/dl and 13.56 mg/dl, and group 4 (ibuprofen dose 7 mg/kg BW and Putri Malu extract of 35 mg/kg BW) showed SGOT and SGPT levels of 28.23 mg/dl and 18.35 mg/dl. The four groups had different mean SGOT and SGPT levels (p 0,000). Conclusion: Leaf extract of the Putri Malu leaf plants (Mimosa pudica Linn) has a chemical effect on hepatoprotection, as shown by the decrease in SGOT and SGPT levels

Item Type:	Article
Uncontrolled Keywords:	Putri; Malu; hepatoprotector; Ibuprofen; SGOT; SGPT; hepatotoxic
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Jurnal > Fakultas Kedokteran
Depositing User:	FAKULTAS KEDOKTERAN KEDOKTERAN
Date Deposited:	19 Jan 2024 08:01
Last Modified:	19 Jan 2024 08:01
URI:	http://repository.um-surabaya.ac.id/id/eprint/8579

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