Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus)

Background: Putri Malu leaf plants (Mimosa pudica Linn) contain flavo
noid compounds beneficial as hepatoprotectors. Putri Malu leaf plant
extract can be useful to prevent problems such as Ibuprofen-induced he
patic damage, but studies that focus on this topic remain scarce in Indo
nesia.
Objective: To prove the extracted content of the leaves of the Putri Malu
plant (Mimosa pudica Linn) as a hepatoprotector of hepatic damage in mice
(Mus musculus) induced by Ibuprofen
Method: This randomized post-test control group design was conducted
at the Experimental Animal Laboratory, Faculty of Veterinary Medicine,
Universitas Airlangga. A total of 28 mice were treated with four condi
tions then underwent SGOT and SGPT blood laboratory tests.
Results: Group P1 (placebo) had SGOT and SGPT levels averaging
23.87 mg/dl and 13.45 mg/dl, group P2 (ibuprofen dose 7 mg/kg BW)
had SGOT and SGPT levels of 29.13 mg/dl and 19.10 mg/dl, group 3
(Putri Malu extract 35 mg/kg BW) had SGOT and SGPT of 24.05 mg/dl
and 13.56 mg/dl, and group 4 (ibuprofen dose 7 mg/kg BW and Putri
Malu extract of 35 mg/kg BW) showed SGOT and SGPT levels of 28.23
mg/dl and 18.35 mg/dl. The four groups had different mean SGOT and
SGPT levels (p 0,000).
Conclusion: Leaf extract of the Putri Malu leaf plants (Mimosa pudica
Linn) has a chemical effect on hepatoprotection, as shown by the decrease
in SGOT and SGPT levels