Bioactivity of Phytochemicals in Curcuma Domestica on Lymphocyte Cell Count in Mice (Mus Musculus)

The immune system or immunity is a system that can protect the human
body against foreign objects that enter the body. People can maintain their immune
system by consuming healthy and nutritious food, exercising regularly, maintaining personal health, taking supplements or immune-boosting vitamins, and consuming traditional herbs, such as juice from the phytochemical Curcuma domestica (turmeric). Curcuma domestica is a tropical plant, and it can find in many parts
of Asia, one of which is Indonesia. The main components of the phytochemical
Curcuma domestica are curcumin and essential oils. In contrast, the phytochemicals of curcumin and essential oils can boost the immune system because they
are proven to increase lymphocyte cells. This study aimed to determine the bioactivity of phytochemicals in Curcuma domestica on the number of lymphocyte
cells in mice (Mus musculus). This study was experimental research with the pre
and post-test design. The sample used in this study was 32 mice divided into two
groups, including control and treatment groups. Data of lymphocyte cells were
analyzed using a manual method, namely peripheral blood smear. The data were
analyzed using the SPSS (Statistical Program Social Science) application using
the independent t-test. The results were p = 0.000 (p 0.05), so Ho was rejected, and
Ha was accepted. The results obtained in the control group showed that the average number of lymphocyte cells before treatment was 42.5%, and after treatment
was 47.5%. While in the treatment group, the average number of lymphocyte
cells before being given the phytochemical extract of Curcuma domestica was
41.75%, and after being given the phytochemical extract of Curcuma domestica
was 57.25%. The conclusion is that giving the phytochemical extract of Curcuma
domestica affects the number of lymphocyte cells in mice (Mus musculus).