s-IgA Uterine Cervix Secretion in Women of Infertile Couples Recognized Microorganism Spectrum of Nonspecific Vaginitis

The prevalence of infertile couples varies between 10-40%. In Indonesia 17%, East Java 26%, Surabaya 25%, Malang 18% and Mojokerto 25%. To explore the possible causes of infertility that occurs in Mojokerto, East Java, Indonesia, I proposed a study to explianed it. The study was conducted by collecting biographical data in general and through clinical examination of all infertile couples. Other collected data included profiles of bacteria found in the vagina and an antibiotic sensitivity test of bacteria that can be isolated. To determine the possibility of antibodies against sperm a western blot examination of bacterial proteins in fluid secretions obtained from the vagina was carried out first. And the results show that microorganisms were identified from the female lower reproductive tract of infertile couples dominated by Staphylococcus aureus (S. aureus) (27%) and Escherichia coli (27%), and the sensitivity tests of antibiotics vary greatly. One of the microorganisms particularly S. aureus that found in large number was done western blotting using s-IgA cervix uteri as an antibody recognized Omp's (outer membrane protein) with molecular weight, 52 kDa, and 49 kDa. So that one of the bacteria species S. aureus that infects the vagina and causes non-specific vaginitis can provoke an adaptive immune response by producing s-IgA. Difference molecular weight (MW) of OMP's S. aureus can stimulate immune response among women of infertile couples.