BIOAKTIFITAS BUNGA SEPATU (Hibiscus rosa-sinensis L.) TERHADAP KADAR KOLESTEROL DARAH MENCIT (Mus musculus) YANG MENGALAMI HIPERKOLESTEROLEMIA DENGAN DIET TINGGI LEMAK

The purpose of this study was to determine the effect of
bioactivity of extract Hibiscus rosa-sinensis L. to blood cholesterol level of mice Mus musculus that experienced hypercholesterolemia with high fat diet. This research is a pure experimental research, using randomized post-test only control group design. Hibiscus rosasinensis L.contains anthocyanin pigment which belongs to flavonoid
group that acts as antioxidant. Twenty-eight mice were divided into four groups (K1, K2, K3 and K4). The K1 group was the group that received high fat treatment and aquadest after acclimation. Groups K2, K3, and K4 are treatment groups treated with high-fat diet, septal
extract of 1 ml and aquadest after acclimation. High-fat feeding lasts 28 days. During the research has been done weighing the mouse five times. The results showed that giving 1 ml of extract Hibiscus rosasinensis L. for twenty eight days can decrease the cholesterol level of Mus musculus where the value of p < 0.05.