An East-Asian-type cagA Helicobacter pylori Infected Patient with Clinical Manifestation of Gastric Ulcer

We reported a male, 72 yo, Chinese ethnic with chief complaint black mushy defecation. Physical examination
revealed pale on conjunctival palpebra which confirmed as anemia on complete blood count. Gastroduodenoscopy
revealed a 3 mm ulcer at the antrum (Forrest stage III). H. pylori infection was positive based on five different
test methods (urinary antibody tests, rapid urease test, culture, histology ad immunohistochemistry). Used
polymerase chain reaction-based sequencing, we found the patient infected by CagA producing, East-Asian-type
cagA and vacA s1m1-strain. Further analysis using 7 housekeeping genes confirmed that the strain categorized
in to hspEAsia group. The patient was given continuous intravenous infusions of proton pump inhibitor and
standard triple therapy regimens eradication of H. pylori.