Pregnancy with Myasthenia Gravis

ABSTRACT
Myasthenia Gravis (MG) is a serious autoimmune disease,
but now can be treated. Symptoms include weakness and
fatigue in voluntary muscles caused by an autoantibody
reaction to nicotinic acetylcholine receptor (AChR) at the
post synapse of the neuromuscular junction. Pregnancy
can affect autoimmune diseases so that pregnancy can
aggravate MG disease. On the other hand it is also reported
that pregnancy does not affect and can even improve MG
disease. In this article, We report a 27-year-old woman
who was diagnosed with myasthenia gravis that having a
pregnancy. Initially she had no problems with pregnancy.
Patients underwent pregnancy by taking the drug
Mestinon four times daily and roborant. But entering the
33rd-34th week, the examination results showed that the
pregnancy experienced oligohydramnios and Intrauterine
Growth Retardation (IUGR), it was probably caused
by malnutrition. Then we decided to end the patient’s
pregnancy with a Caesarean section. The operation went
well, born to a baby boy / 2450grams / Apgar Score
5-7. Observation for one week the mother’s condition
continued to improve. Diplopia and weaknesses also
improve. Likewise the baby showed a healthy condition.
The patient was discharged while still taking MG drugs
that had been previously consumed. This case report
showed that pregnancy worsened MG disease, but MG did
not affect pregnancy