Background: Breast Self Examination (BSE) behavior in teenagers is essential for the early detection of breast cancer. BSE is a cheap and easy way to detect early. The incidence of breast cancer in Indonesia is significant, and the mortality rate can not be separated due to a lack of awareness. BSE health education is one of the factors that can influence BSE behavior, which includes knowledge, attitudes, and actions. With the formation of BSE behavior, if health workers can immediately check found abnormalities or changes in the breast. Besides and can directly get therapy and, in the long term, can reduce the mortality rate of breast cancer. Purpose: To determine the effect of health education on behavior (knowledge, attitudes, and actions) BSE students of Madrasah Aliyah Islamic Boarding School Ar-Raudlatul Ilmiyah Kertosono. Method: This research is a trueexperimental study with the posttest-only control group design. Tools used to collect data knowledge, attitude, and action is a questionnaire. The analysis is only made at the posttest-only. Result: The results of the analysis in the knowledge, attitude, and action questionnaire obtain a Pearson correlation >0.444, p-value < 0,05, and Cronbach alpha value >0.6. Independent T-Test obtained significance values (p <0.05) from each domain that is equal to 0.00 in the knowledge domain, 0.00 in the attitude domain, 0.03 in the action domain, and 0.00 in the total behavior score. Conclusion: The questionnaire is valid and reliable. There is a significant influence of BSE health education on behavior, knowledge, attitudes, and actions