Efektifitas Pemberian Hidrogel Ekstrak Daun Pegagan (Centella asiatica) Terhadap Pertumbuhan Staphylococcus aureus

Eczema or atopic dermatitis is a skin problem that can
disrupt appearance and undermine confidence due to its tendency
to cause itching. Excessive scratching can lead to inflammation,
making the skin susceptible to infections. Current eczema
treatments involve both non-pharmacological and pharmacological
therapies, which are time-consuming and costly. Therefore, an
alternative treatment using a hydrogel formulation derived from the
extract of gotu kola leaves (Centella asiatica) is proposed. Gotu
kola is a plant known for its antimicrobial properties, with active
compounds capable of inhibiting bacterial growth. The aim of this
research is to determine the concentration of gotu kola leaf extract
and assess the effectiveness of the hydrogel formulation in inhibiting
the growth of Staphylococcus aureus. The extraction of gotu kola
leaves is carried out through the maceration process using ethanol
as a solvent. The antibacterial properties are evaluated using the
well diffusion method. Extract concentrations of 2.5%, 5%, 7.5%,
30%, 50%, and 75% are prepared, with a positive control using the
antibiotic Clindamycin. The average clear zone diameter obtained
is 15.25 mm. At a concentration of 2.5%, the clear zone diameter is
4.5 mm, at 5% it is 5 mm, and at 7.5% it is 7 mm. Meanwhile, the
second treatment with concentrations of 30%, 50%, and 75% yields
clear zones of 24 mm, 27 mm, and 27 mm, respectively, compared
to the positive control with a zone of 24 mm. These results indicate
that gotu kola leaf extract exhibits antibacterial activity against
Staphylococcus aureus, with a concentration of 75% being sensitive
and able to inhibit the bacterial growth rate, resulting in a clear
zone of 27 mm.
Keywords : Eczema, Hydrogel,